Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
1987-8-20
pubmed:abstractText
Inhibin, a gonadal hormone capable of preferential suppression of pituitary follicle-stimulating hormone (FSH) secretion, has recently been purified. The major form of this protein is an alpha beta heterodimer encoded by two separate genes. In contrast to the FSH-suppressing action of the alpha beta heterodimer, the beta beta homodimer stimulates FSH secretion. Luteinizing hormone (LH)-secreting pituitary cells and gonadal androgen-producing cells have long been shown to form a closed-loop feedback axis. Based on recent studies demonstrating the FSH stimulation of inhibin biosynthesis by ovarian granulosa and testis Sertoli cells, an additional closed-loop feedback axis exists between pituitary FSH- and gonadal inhibin-producing cells. Because uncharacterized Sertoli cell factors have been suggested to either stimulate or inhibit androgen production by testicular Leydig cells, we have tested the intragonadal paracrine actions of heterodimers and homodimers of inhibin subunits. In primary cultures of testis cells, the alpha beta heterodimer of inhibin enhances Leydig cell androgen biosynthesis stimulated by LH, whereas the beta beta homodimer suppresses androgen production. Furthermore, similar modulatory actions of inhibin-related proteins were found in cultured ovarian theca-interstitial cells and theca explants treated with LH. In contrast, treatment with the inhibin-related proteins alone did not affect gonadal steroidogenesis. Our data indicate that the inhibin-related gene products synthesized by Sertoli and granulosa cells may form heterodimers or homodimers to serve as intragonadal paracrine signals in the modulation of LH-stimulated androgen biosynthesis and allow cross-communication between the two feedback loops.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-121176, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-17815236, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-189319, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-2417121, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-271996, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-2987067, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-3004924, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-3012369, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-3023019, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-3030853, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-3081385, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-3086749, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-3087350, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-3458167, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-3470005, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-371953, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-3754442, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-3754790, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-3864157, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-3888612, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-3918529, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-3933509, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-4007258, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-4015638, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-4074357, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-6142819, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-6250797, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-6291906, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-6489602, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-6781494, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-6812179, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-712297, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-954678, http://linkedlifedata.com/resource/pubmed/commentcorrection/3474640-958466
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5082-6
pubmed:dateRevised
2010-9-10
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Heterodimers and homodimers of inhibin subunits have different paracrine action in the modulation of luteinizing hormone-stimulated androgen biosynthesis.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't