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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1987-6-25
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pubmed:abstractText |
Liver peroxisomes were isolated from di(2-ethylhexyl)phthalate treated rats by isopycnic sucrose gradient centrifugation of a light mitochondrial fraction. Incubation of prostaglandin F2 alpha with purified peroxisomes resulted in conversion into a more polar product(s). In contrast, incubation with mitochondrial fractions and microsomal fractions under the same conditions did not result in any detectable conversion. The polar material obtained from a preparative incubation was purified by high performance liquid chromatography and characterized by radio-gas chromatography and gas chromatography-mass spectrometry. The structure of the polar compound was shown to be 5,7,11-trihydroxy-tetranorprost-9-enoic acid (tetranor-prostaglandin F1 alpha). Prostaglandin F2 alpha was thus chain-shortened by four carbon atoms.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0006-291X
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
14
|
pubmed:volume |
144
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1206-13
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3472523-Animals,
pubmed-meshheading:3472523-Cell Fractionation,
pubmed-meshheading:3472523-Chromatography, Gas,
pubmed-meshheading:3472523-Chromatography, High Pressure Liquid,
pubmed-meshheading:3472523-Dinoprost,
pubmed-meshheading:3472523-Kinetics,
pubmed-meshheading:3472523-Liver,
pubmed-meshheading:3472523-Male,
pubmed-meshheading:3472523-Microbodies,
pubmed-meshheading:3472523-Prostaglandins F,
pubmed-meshheading:3472523-Rats,
pubmed-meshheading:3472523-Rats, Inbred Strains
|
pubmed:year |
1987
|
pubmed:articleTitle |
Chain-shortening of prostaglandin F2 alpha by rat liver peroxisomes.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|