Linked Life Data

3471898

Source:http://linkedlifedata.com/resource/pubmed/id/3471898

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1987-6-5
pubmed:abstractText
Angiotensin II (ANG II) binding sites were quantified in individual adrenal and pituitary glands and brain nuclei of sino-aortic denervated (neurogenically hypertensive) and sham-operated rats by incubation of 16-microns tissue sections with 125I-[Sar1] Ang II, autoradiography, computerized microdensitometry and comparison with 125I-standards. In the anterior pituitary, the number of ANG II binding sites (Bmax) was increased in sino-aortic denervated rats, 764 +/- 39 versus 2025 +/- 340 fmol/mg protein in sham-operated versus sino-aortic denervated. In the adrenal medulla the Bmax was decreased in sino-aortic denervated rats, 3313 +/- 71 versus 2736 +/- 181 fmol/mg protein in sham-operated versus sino-aortic denervated. There were no significant changes in adrenal zona glomerulosa ANG II binding capacity. In the nucleus of the solitary tract the Bmax was decreased, from 1422 +/- 22 fmol/mg protein in sham-operated to 370 +/- 52 fmol/mg protein in sino-aortic denervated rats. These results indicate that changes in ANG II binding occur in peripheral tissues and brain of neurogenic hypertensive rats. Our findings suggest that both peripheral and central ANG II may be associated with the pathophysiology of neurogenic hypertension.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0952-1178
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S154-7
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Angiotensin II receptors in adrenal gland, pituitary gland and brain of sino-aortic denervated rats.
pubmed:publicationType
Journal Article