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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1987-5-4
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pubmed:databankReference |
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pubmed:abstractText |
The arrangement of immunoglobulin genes has been examined in a series of lymphoid cell lines transformed with the Harvey murine sarcoma virus. One cell line, HAFTL-1, expresses antigenic markers characteristic of B-lymphoid cells and undergoes frequent rearrangement at the JH locus (where J = joining and H = heavy chain) during propagation in culture. By molecular cloning and nucleotide sequence determination, these rearrangements were found to represent the earliest postulated step in heavy chain gene assembly: the joining of a diversity (D) segment to a JH segment. The HAFTL-1 cell line also undergoes infrequent D beta-to-J beta joining at the T-cell receptor beta locus in culture. The observations presented here suggest that the HAFTL-1 cell line represents the early stage of B-cell differentiation at which immunoglobulin gene rearrangement is initiated.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-111144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-115000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-178822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-222460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-2578321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-2985470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-3009204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-3088206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-322279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-3484682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-3875679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6086308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6090932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6092962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6092963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6251474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6265323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6277505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6286838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6287467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6291785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6295879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6299581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6300689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6312838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6324169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6328306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6331676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6611207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6611508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6769593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6773666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6774258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6774416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6776532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6783961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6783962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6787586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6787590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6798155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-6806823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3470759-881736
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1799-803
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3470759-Animals,
pubmed-meshheading:3470759-Base Sequence,
pubmed-meshheading:3470759-Cell Line,
pubmed-meshheading:3470759-Cell Transformation, Neoplastic,
pubmed-meshheading:3470759-Cloning, Molecular,
pubmed-meshheading:3470759-DNA,
pubmed-meshheading:3470759-Genes,
pubmed-meshheading:3470759-Harvey murine sarcoma virus,
pubmed-meshheading:3470759-Immunoglobulins,
pubmed-meshheading:3470759-Mice,
pubmed-meshheading:3470759-Oncogenes,
pubmed-meshheading:3470759-Receptors, Antigen, T-Cell
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pubmed:year |
1987
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pubmed:articleTitle |
Continuing rearrangement of immunoglobulin and T-cell receptor genes in a Ha-ras-transformed lymphoid progenitor cell line.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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