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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1987-2-24
|
| pubmed:abstractText |
We use murine erythroid Friend cells and human promyelocytic HL60 cells to investigate the influence of a transmembrane signal in triggering myeloid or erythroid cell differentiation. Combined treatments were given with dimethylsulfoxide, actinomycin D and amphotericin B, a substance which resembles a deviant membrane lipid and which seems to influence exclusively membrane activity. Our results suggest that a membrane modification alone is sufficient for in vitro HL60 cell differentiation, whereas both a transmembrane and a nuclear signal are necessary for Friend cell differentiation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0300-8916
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
31
|
| pubmed:volume |
72
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
545-51
|
| pubmed:dateRevised |
2008-12-12
|
| pubmed:meshHeading |
pubmed-meshheading:3468673-Amphotericin B,
pubmed-meshheading:3468673-Cell Differentiation,
pubmed-meshheading:3468673-Cell Division,
pubmed-meshheading:3468673-Cell Line,
pubmed-meshheading:3468673-Dactinomycin,
pubmed-meshheading:3468673-Dimethyl Sulfoxide,
pubmed-meshheading:3468673-Drug Synergism,
pubmed-meshheading:3468673-Friend murine leukemia virus,
pubmed-meshheading:3468673-Humans,
pubmed-meshheading:3468673-Kinetics,
pubmed-meshheading:3468673-Leukemia, Erythroblastic, Acute,
pubmed-meshheading:3468673-Leukemia, Myeloid, Acute
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
The influence of amphotericin B on differentiation induced by dimethylsulfoxide and actinomycin D in HL60 and Friend cell lines.
|
| pubmed:publicationType |
Journal Article
|