Linked Life Data

3468290

Source:http://linkedlifedata.com/resource/pubmed/id/3468290

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-3-11
pubmed:abstractText
The effect of physiologic common free fatty acids (FFAs) on Mat 1376b ascites tumor cells in vitro and in vivo in F344 rats was investigated. Unsaturated fatty acids, such as palmitoleic (16:1), oleic (18:1), linoleic (18:2), linolenic (18:3), and arachidonic (20:4) acids, were significantly more effective killers of tumor cells in vitro than the corresponding saturated fatty acids of the same carbon length, including palmitic (16:0), stearic (18:0), and arachidic (20:0) acids. The saturated 16-carbon fatty acid (palmitic acid) was more toxic to tumor cells in vitro than the saturated 18-carbon (stearic) and 20-carbon (arachidic) acids. Injections of linoleic (18:2)-linolenic (18:3) acid combinations into rats inoculated with the tumor significantly enhanced the survival of the tumor-bearing animals. These results suggest that natural FFAs may under certain conditions be utilized as effective anticancer agents.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0027-8874
pubmed:author
pubmed:issnType
Print
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
271-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Cytotoxic effects of free fatty acids on ascites tumor cells.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't