Linked Life Data

3467494

Source:http://linkedlifedata.com/resource/pubmed/id/3467494

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1987-2-2
pubmed:abstractText
Cynomolgus monkeys were treated twice daily in one eye with timolol 180 micrograms for 2.7, 6.0, or 7.4 months (2 monkeys for each period) or epinephrine 540-600 micrograms for 6.7 months (2 monkeys). Some ciliary processes in both eyes of all timolol-treated monkeys exhibited light and electron microscopic changes consistent with decreased secretion: narrowed stromal vessels with few fenestrations surrounded by a thickened fibre sheath; thickened PE basement membrane; few PE and NPE basolateral infoldings; flattened NPE with small mitochondria. Additionally, the NPE contained pigment granules and large phagolysosomes. The processes in both eyes of the epinephrine-treated monkeys exhibited one of two pictures: dilated stromal capillaries with numerous fenestrations; normal stroma, PE basement membrane and PE; numerous well-developed NPE basolateral infoldings and enlarged mitochondria; dilated stromal capillaries with ruptured fenestrations; ballooned protein-filled stroma; degenerated NPE. The first picture could be consistent with hypersecretion, the second with hyposecretion. Possible pathophysiological explanations and implications of these findings are discussed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0078-5334
pubmed:author
pubmed:issnType
Print
pubmed:volume
105 ( Pt 2)
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
180-95
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Long-term timolol and epinephrine in monkeys. I. Functional morphology of the ciliary processes.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't