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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1987-1-9
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pubmed:abstractText |
3H-Labeled prostaglandins D2 and F2 alpha rapidly degraded to more-polar metabolites in primary cultured rat hepatocytes. The metabolites of prostaglandins D2 and F2 alpha accumulated in the culture medium. The metabolites extracted by ethyl acetate at pH 3 were purified by silicic acid column and thin-layer chromatography of silica gel, and were analysed by gas chromatography-mass spectrometry. The major metabolites from prostaglandin D2 were identified as dinor-prostaglandin D1 (7 alpha,13-dihydroxy-9-ketodinorprost-11-enoic acid) and tetranor-prostaglandin D1 (5 alpha,11- dihydroxy-7-ketotetranorprost-9-enoic acid). Those from prostaglandin F2 alpha were identified as dinor-prostaglandin F1 alpha (7 alpha,9 alpha,13-trihydroxydinorprost-11-enoic acid), tetranor-prostaglandin F1 alpha (5 alpha,7 alpha,11-trihydroxytetranorprost-9-enoic acid) and 9 alpha,11 alpha,15-trihydroxyprost-13-ene-1,20-dioic acid. These data indicate that prostaglandins D2 and F2 alpha mainly degraded by beta-oxidation, which is the same process as reported earlier for prostaglandins E1 and E2, and that prostaglandin F2 alpha was also subjected to omega-oxidation.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprost,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin D2,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandins D,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandins F,
http://linkedlifedata.com/resource/pubmed/chemical/Tritium
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0006-3002
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
879
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
330-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3465372-Animals,
pubmed-meshheading:3465372-Cells, Cultured,
pubmed-meshheading:3465372-Chromatography, Gas,
pubmed-meshheading:3465372-Chromatography, Thin Layer,
pubmed-meshheading:3465372-Dinoprost,
pubmed-meshheading:3465372-Kinetics,
pubmed-meshheading:3465372-Liver,
pubmed-meshheading:3465372-Male,
pubmed-meshheading:3465372-Mass Spectrometry,
pubmed-meshheading:3465372-Prostaglandin D2,
pubmed-meshheading:3465372-Prostaglandins D,
pubmed-meshheading:3465372-Prostaglandins F,
pubmed-meshheading:3465372-Rats,
pubmed-meshheading:3465372-Rats, Inbred Strains,
pubmed-meshheading:3465372-Tritium
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pubmed:year |
1986
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pubmed:articleTitle |
Metabolism of prostaglandins D2 and F2 alpha in primary cultures of rat hepatocytes.
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pubmed:publicationType |
Journal Article
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