Linked Life Data

3465192

Source:http://linkedlifedata.com/resource/pubmed/id/3465192

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1986-12-17
pubmed:abstractText
The possible physiological significance of low concentrations of Hg2+ in the guinea-pig ileum has been investigated. Responses to nerve stimulation by single electrical shocks, acetylcholine (ACh), and histamine (Hi) and the response to ACh of a depolarized preparation were examined. A stimulant effect of Hg2+, in the concentration range of 10 nM-1 microM, dominated in intestine accommodated in biological saline solution. This excitatory effect was probably mainly due to stimulation of a depolarization-coupled initiation of the contraction. The inhibitory effect of Hg2+, 10 nM-1 microM, observed in depolarized muscle was presumably due to a decreased Ca2+ availability for the contractile process. In the higher concentration range, 1-100 microM, a probably direct action on the contractile elements causing irreversible deterioration of the preparation seems to be present.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0001-6357
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
207-13
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Effects of mercuric ions on isolated guinea-pig ileum.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't