Linked Life Data

346495

Source:http://linkedlifedata.com/resource/pubmed/id/346495

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1978-6-12
pubmed:abstractText
Studies were initiated to determine the effects of the different phases of the nematode life cycle on the delayed-type hypersensitivity (DTH) capabilities of the host. Mice were injected intraperitoneally with 4 X 10(6) viable or heat-killed BCG at 0, 3, 7, 14 and 28 days after oral infection with 200 Trichinella spiralis larvae. Groups were tested for DTH 28 days after BCG inoculation by the footpad swelling assay. Infection with T. spiralis was found to suppress the response in mice administered viable BCG 0 or 3 days later. Mice injected with viable bacteria 7 days after T. spiralis regained the ability to develop in vivo DTH reactions against old tuberculin. Groups administered viable BCG 14 and 28 days after nematode infection yielded potentiated DTH responses, when compared with control mice. Animals infected with T. spiralis and later injected with heat-killed BCG required a longer interval to develop specific immunopotentiation. Maximum immunopotentiation seemed to be related to the presence of larvae in muscle tissue (28 days). These findings suggest that the effect of T. spiralis on the immune capabilities of the host is dependent on the different anatomical locations of the parasite.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0020-5915
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8-14
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Effect of Trichinella spiralis infection on delayed hypersensitivity to heterologous antigens.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.