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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1986-12-16
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pubmed:abstractText |
PGD2 dose dependently potentiated the parasympathetic-induced contraction in guinea-pig trachea in vitro. This phenomenon was much more evident in ovalbumin-sensitized guinea-pig trachea. Indomethacin pretreatment enhanced the capacity of PGD2 to potentiate cholinergic-induced contraction in normal but not in ovalbumin-sensitized guinea-pig. PGD2 shifted to the left the curve of the exogenous acetylcholine-induced contraction in guinea-pig trachea, indicating a postsynaptic site of action of PGD2. These data suggest a role of PGD2 in the genesis of hyperreactivity of tracheal smooth muscles, particularly in a model of pulmonary anaphylaxis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0144-1795
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
181-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3464602-Acetylcholine,
pubmed-meshheading:3464602-Animals,
pubmed-meshheading:3464602-Dinoprost,
pubmed-meshheading:3464602-Electric Stimulation,
pubmed-meshheading:3464602-Guinea Pigs,
pubmed-meshheading:3464602-Indomethacin,
pubmed-meshheading:3464602-Male,
pubmed-meshheading:3464602-Muscle, Smooth,
pubmed-meshheading:3464602-Muscle Contraction,
pubmed-meshheading:3464602-Parasympathetic Nervous System,
pubmed-meshheading:3464602-Prostaglandin D2,
pubmed-meshheading:3464602-Prostaglandins D,
pubmed-meshheading:3464602-Prostaglandins F,
pubmed-meshheading:3464602-Trachea
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pubmed:year |
1986
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pubmed:articleTitle |
Prostaglandin D2 (PGD2) potentiates cholinergic responsiveness in guinea-pig trachea.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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