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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
1986-10-3
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pubmed:abstractText |
Computer graphics model building and molecular mechanical calculations have been carried out on d(CGTACG)2 and its bis-intercalation complexes with triostin A and an N-Me-Ala analogue of triostin A. Two conformations of the DNA have been considered both for the uncomplexed and for complexed nucleic acid: in one the central A - T base pairs are Watson-Crick base paired; in the other they are Hoogsteen base paired. The calculations offer a clear explanation why Hoogsteen base pairing is not favorable in isolated A + T-rich DNA and also suggest reasons why the bis-intercalation of triostin A might help stabilize the neighboring A - T base pairs into a Hoogsteen form. To our knowledge, this is the first study to use molecular mechanical and dynamical methods to investigate the bis-intercalator-DNA complex.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3462702-13054692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3462702-17773334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3462702-2983343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3462702-3006816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3462702-3856228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3462702-4000957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3462702-4437614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3462702-5040245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3462702-6089341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3462702-6204275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3462702-6386526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3462702-6474168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3462702-687364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3462702-7171723
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6402-6
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pubmed:dateRevised |
2010-9-10
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pubmed:meshHeading |
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pubmed:year |
1986
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pubmed:articleTitle |
Molecular mechanical studies of d(CGTACG)2: complex of triostin A with the middle A - T base pairs in either Hoogsteen or Watson-Crick pairing.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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