| pubmed-article:3461478 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3461478 | lifeskim:mentions | umls-concept:C0221284 | lld:lifeskim |
| pubmed-article:3461478 | lifeskim:mentions | umls-concept:C1512668 | lld:lifeskim |
| pubmed-article:3461478 | lifeskim:mentions | umls-concept:C0011209 | lld:lifeskim |
| pubmed-article:3461478 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:3461478 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:3461478 | pubmed:dateCreated | 1986-9-25 | lld:pubmed |
| pubmed-article:3461478 | pubmed:abstractText | Heat-sensitive immunoliposomes are capable of releasing the entrapped content at the target cell surface upon a brief heating to the phase transition temperature of the liposome membrane. In this study we have examined the delivery efficiency of drugs entrapped in heat-sensitive immunoliposomes. Immunoliposomes composed of dipalmitoyl phosphatidylcholine with entrapped [3H]uridine were incubated with target cells at 4 degrees C. The cell-liposome mixture was then heated to 41 degrees C and the uptake of [3H]uridine into the intracellular pool of phosphorylated uridine-containing molecules was measured. The immunoliposomes showed maximal release of the uridine at 41 degrees C, the phase transition temperature of dipalmitoyl phosphatidylcholine liposomes. The largest accumulation of [3H]uridine in the target cells also took place at 41 degrees C. The initial level of uptake of [3H]uridine released from immunoliposomes by heating was greatly enhanced over that observed for free [3H]uridine and [3H]uridine released from liposomes without attached antibody. The nucleoside uptake inhibitors nitrothiobenzylinosine, dipyridamole, and unlabeled uridine were able to inhibit uptake of [3H]uridine released from immunoliposomes. This supports the hypothesis that the enhanced uptake is due to a heat-induced release of [3H]uridine at the cell surface followed by transport and phosphorylation of [3H]uridine by the target cells. These results indicate the feasibility of using the heat-sensitive immunoliposomes as a target-specific drug delivery system. | lld:pubmed |
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| pubmed-article:3461478 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3461478 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3461478 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3461478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3461478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3461478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3461478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3461478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3461478 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3461478 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:3461478 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:3461478 | pubmed:author | pubmed-author:HuangLL | lld:pubmed |
| pubmed-article:3461478 | pubmed:author | pubmed-author:SullivanS MSM | lld:pubmed |
| pubmed-article:3461478 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3461478 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:3461478 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3461478 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3461478 | pubmed:pagination | 6117-21 | lld:pubmed |
| pubmed-article:3461478 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3461478 | pubmed:meshHeading | pubmed-meshheading:3461478-... | lld:pubmed |
| pubmed-article:3461478 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3461478 | pubmed:articleTitle | Enhanced delivery to target cells by heat-sensitive immunoliposomes. | lld:pubmed |
| pubmed-article:3461478 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3461478 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3461478 | lld:pubmed |
