| pubmed-article:3461311 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3461311 | lifeskim:mentions | umls-concept:C0030193 | lld:lifeskim |
| pubmed-article:3461311 | lifeskim:mentions | umls-concept:C0025148 | lld:lifeskim |
| pubmed-article:3461311 | lifeskim:mentions | umls-concept:C0001629 | lld:lifeskim |
| pubmed-article:3461311 | lifeskim:mentions | umls-concept:C1550278 | lld:lifeskim |
| pubmed-article:3461311 | lifeskim:mentions | umls-concept:C0521329 | lld:lifeskim |
| pubmed-article:3461311 | lifeskim:mentions | umls-concept:C0205322 | lld:lifeskim |
| pubmed-article:3461311 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:3461311 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:3461311 | lifeskim:mentions | umls-concept:C0599861 | lld:lifeskim |
| pubmed-article:3461311 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:3461311 | pubmed:dateCreated | 1986-9-16 | lld:pubmed |
| pubmed-article:3461311 | pubmed:abstractText | To confirm that endogenous opioid-peptidergic systems and monoaminergic systems participate in the regulation of pain, the effects of a narcotic antagonist naloxone, inhibitors of enkephalin-degrading enzymes and monoaminergic blockers on persistent pain induced by formalin were investigated. Rats were given formalin into the plantar region of the left hind-paw and the duration of licking responses was measured at periods of 0-10 min (period I), 10-30 min (period II), 30-60 min (period III) and 60-120 min (period IV). Naloxone was administered systemically through mini-osmotic pumps and there was an enhanced licking response at period III and a tendency toward enhancement at period IV. The duration of the licking response at period III was increased when naloxone was given into the fourth ventricle in a dose of 30 nmol/rat, but not when it was injected into the lumbo-sacral subarachnoid space in doses of 30 and 300 nmol/rat. Thiorphan and bestatin injected simultaneously into the fourth ventricle (50 micrograms/rat) depressed the licking response at period III. Intrathecal injection of phentolamine significantly enhanced the licking response at periods I-III and produced a similar, but weaker effect at period IV. Intrathecal injection of propranolol and methysergide did not affect the response. These results suggest that opioid-peptidergic systems in the brain stem and noradrenergic systems in the spinal cord (via alpha-adrenoceptors) participate in the regulation of pain. | lld:pubmed |
| pubmed-article:3461311 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3461311 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3461311 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3461311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3461311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3461311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3461311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3461311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3461311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3461311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3461311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3461311 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3461311 | pubmed:month | May | lld:pubmed |
| pubmed-article:3461311 | pubmed:issn | 0028-3908 | lld:pubmed |
| pubmed-article:3461311 | pubmed:author | pubmed-author:TakagiHH | lld:pubmed |
| pubmed-article:3461311 | pubmed:author | pubmed-author:SatohMM | lld:pubmed |
| pubmed-article:3461311 | pubmed:author | pubmed-author:SugimotoMM | lld:pubmed |
| pubmed-article:3461311 | pubmed:author | pubmed-author:KuraishiYY | lld:pubmed |
| pubmed-article:3461311 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3461311 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:3461311 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3461311 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3461311 | pubmed:pagination | 481-5 | lld:pubmed |
| pubmed-article:3461311 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:3461311 | pubmed:meshHeading | pubmed-meshheading:3461311-... | lld:pubmed |
| pubmed-article:3461311 | pubmed:meshHeading | pubmed-meshheading:3461311-... | lld:pubmed |
| pubmed-article:3461311 | pubmed:meshHeading | pubmed-meshheading:3461311-... | lld:pubmed |
| pubmed-article:3461311 | pubmed:meshHeading | pubmed-meshheading:3461311-... | lld:pubmed |
| pubmed-article:3461311 | pubmed:meshHeading | pubmed-meshheading:3461311-... | lld:pubmed |
| pubmed-article:3461311 | pubmed:meshHeading | pubmed-meshheading:3461311-... | lld:pubmed |
| pubmed-article:3461311 | pubmed:meshHeading | pubmed-meshheading:3461311-... | lld:pubmed |
| pubmed-article:3461311 | pubmed:meshHeading | pubmed-meshheading:3461311-... | lld:pubmed |
| pubmed-article:3461311 | pubmed:meshHeading | pubmed-meshheading:3461311-... | lld:pubmed |
| pubmed-article:3461311 | pubmed:meshHeading | pubmed-meshheading:3461311-... | lld:pubmed |
| pubmed-article:3461311 | pubmed:meshHeading | pubmed-meshheading:3461311-... | lld:pubmed |
| pubmed-article:3461311 | pubmed:meshHeading | pubmed-meshheading:3461311-... | lld:pubmed |
| pubmed-article:3461311 | pubmed:meshHeading | pubmed-meshheading:3461311-... | lld:pubmed |
| pubmed-article:3461311 | pubmed:meshHeading | pubmed-meshheading:3461311-... | lld:pubmed |
| pubmed-article:3461311 | pubmed:meshHeading | pubmed-meshheading:3461311-... | lld:pubmed |
| pubmed-article:3461311 | pubmed:meshHeading | pubmed-meshheading:3461311-... | lld:pubmed |
| pubmed-article:3461311 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3461311 | pubmed:articleTitle | Involvement of medullary opioid-peptidergic and spinal noradrenergic systems in the regulation of formalin-induced persistent pain. | lld:pubmed |
| pubmed-article:3461311 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3461311 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3461311 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3461311 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3461311 | lld:pubmed |
