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rdf:type |
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lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0010453,
umls-concept:C0040715,
umls-concept:C0175668,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0599718,
umls-concept:C0599813,
umls-concept:C0599893,
umls-concept:C1518453,
umls-concept:C1522702,
umls-concept:C1533691,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C1704928,
umls-concept:C1879547,
umls-concept:C1947973
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pubmed:issue |
4
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pubmed:dateCreated |
1986-3-28
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pubmed:abstractText |
Localization of cellular oncogenes (c-onc) near the break points of translocations in tumor cells has indicated involvement of these genes in neoplastic growth. Enhanced transcription of the cellular homolog (c-abl) of the transforming sequence of Abelson murine leukemia virus was observed in K3D, which was one of the cloned cell lines of 7,12-dimethylbenz[a]anthracene-induced rat erythroblastic leukemia. Since the c-abl activation was not observed in the parent cell line (K2D) from which K3D was derived and the latter was different from the former in the presence of a new marker chromosome, t(3;12), this marker may play a role in the expression of c-abl in K3D cells. In contrast to the human c-onc assignments, few rat c-onc assignments have been reported. In situ molecular hybridization studies assigned c-abl to the 3q12 site of the normal chromosome 3 and to the break point of the translocation t(3;12) in K3D cells. Another break point in this translocation chromosome 12p11 involves the nucleolar region, and the 3;12 translocation may involve c-abl and nucleolar cistrons. These results provide evidence of secondary c-onc activation during karyotypic evolution of cloned malignant cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-1065618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-3856862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-4136731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-415146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-4508329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-5220873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-6159641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-6204766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-6257398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-6290316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-6290897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-6293057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-6316147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-6320178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-6356357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-6360563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-6378364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-6538699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-6580527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-6766514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-6775816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-6818551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-6960256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-6961456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-7116323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-7133135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-7273954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-7284984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-85618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3456563-914873
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1079-83
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3456563-Abelson murine leukemia virus,
pubmed-meshheading:3456563-Animals,
pubmed-meshheading:3456563-Cell Line,
pubmed-meshheading:3456563-Chromosomes,
pubmed-meshheading:3456563-DNA, Neoplasm,
pubmed-meshheading:3456563-DNA, Recombinant,
pubmed-meshheading:3456563-Gene Expression Regulation,
pubmed-meshheading:3456563-Genes, Viral,
pubmed-meshheading:3456563-Genetic Markers,
pubmed-meshheading:3456563-Leukemia, Erythroblastic, Acute,
pubmed-meshheading:3456563-Leukemia, Experimental,
pubmed-meshheading:3456563-Nucleic Acid Hybridization,
pubmed-meshheading:3456563-Nucleolus Organizer Region,
pubmed-meshheading:3456563-Oncogenes,
pubmed-meshheading:3456563-Proto-Oncogenes,
pubmed-meshheading:3456563-Rats,
pubmed-meshheading:3456563-Translocation, Genetic
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pubmed:year |
1986
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pubmed:articleTitle |
Secondary activation of c-abl may be related to translocation to the nucleolar organizer region in an in vitro cultured rat leukemia cell line (K3D).
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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