Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1986-3-13
|
| pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Breast Cancer--etiology,
http://linkedlifedata.com/resource/pubmed/keyword/Breast Cancer--prevention and control,
http://linkedlifedata.com/resource/pubmed/keyword/Cancer,
http://linkedlifedata.com/resource/pubmed/keyword/Contraception,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, Female,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Methods,
http://linkedlifedata.com/resource/pubmed/keyword/Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System,
http://linkedlifedata.com/resource/pubmed/keyword/Estrogens,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/Neoplasms,
http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Population At Risk,
http://linkedlifedata.com/resource/pubmed/keyword/Reproductive Control Agents,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0020-7136
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
37
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
173-7
|
| pubmed:dateRevised |
2007-7-24
|
| pubmed:otherAbstract |
PIP: This report summarizes the conclusions of the 2nd conference of the Multidisciplinary Project on Breast Cancer of the International Union Against Cancer held in 1985. The incidence of breast cancer is rising all over the world and ranges from 0.2-8%/year. There were an estimated 541,000 cases of breast cancer diagnosed in 1975 and over 800,000/year are expected by the year 2000. The increased risk associated with early age at menarche, late age at menopause, late age at 1st birth, and nulliparity suggests the overwhelming importance of ovarian activity in the etiology of breast cancer. No consistent and coherent pattern of endocrine abnormalities associated with breast cancer has been identified, but there is considerable doubt concerning the validity of the concept that estrogen action on the breast is modulated by variations is progesterone secretion. Dietary factors, especially animal fat or meat consumption, are receiving attention. If diet is important, it has to act in childhood or adolescence. The increased risk of breast cancer in women with benign breast disease appears to be restricted to a small proportion of women whose biopsies show atypical hyperplasia. Evidence from a number of recent studies suggests that oral contraceptives (OCs) do not increase the overall risk of breast cancer, although concern has been expressed about numerous subgroups of OC users: women who continue taking OCs around the time of menopause, those who use OCs to delay their 1st pregnancy, and women exposed to prolonged use before age 25 years. Studies of noncontraceptive hormones suggest increased risk occurs only after 10 years or more of use. The prevention of breast cancer was considered in relation to specific agents used as prophylactics in high risk groups and life-style changes. For example, the antiestrogen tamoxifen could be considered for an interventive trial in high-risk women, although problems of toxicity must be considered. Reduction in obesity, especially in postmenopausal women, and a relatively low fat intake are 2 life-style alterations that seem feasible.
|
| pubmed:meshHeading |
pubmed-meshheading:3455923-Breast Diseases,
pubmed-meshheading:3455923-Breast Neoplasms,
pubmed-meshheading:3455923-Contraceptives, Oral,
pubmed-meshheading:3455923-Diet,
pubmed-meshheading:3455923-Female,
pubmed-meshheading:3455923-Genetic Markers,
pubmed-meshheading:3455923-Hormones,
pubmed-meshheading:3455923-Humans,
pubmed-meshheading:3455923-Menopause,
pubmed-meshheading:3455923-Menstruation,
pubmed-meshheading:3455923-Parity,
pubmed-meshheading:3455923-Radiography,
pubmed-meshheading:3455923-Risk
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
UICC Multidisciplinary Project on Breast Cancer: the epidemiology, aetiology and prevention of breast cancer.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|