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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1986-2-19
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pubmed:abstractText |
We have identified an intracellular form of the alpha subunit of the acetylcholine receptor that binds alpha-bungarotoxin with high affinity. Unlike the mature receptor complex, an alpha 2 beta gamma delta pentamer that migrates as a 9S species in velocity sedimentation analysis, the intracellular species moves as a 5S component. The kinetics of appearance of alpha subunit in the 5S component and the mature receptor complex indicate that the intracellular 5S component is a precursor of the mature receptor. The precursor species differs from 9S receptor in two critical features: (i) the precursor alpha subunit is not associated with beta subunit and (ii) alpha-bungarotoxin binding to the precursor alpha subunit is not inhibited by the cholinergic ligands decamethonium or d-tubocurarine. The properties of the precursor suggest that the acquisition of the ligand binding site by alpha subunit occurs at a distinct stage in the posttranslational development of functional acetylcholine receptor.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3455784-11894953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3455784-236319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3455784-2993547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3455784-3838201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3455784-6113245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3455784-6167581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3455784-6208568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3455784-6291077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3455784-6344089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3455784-6480577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3455784-6547444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3455784-6576369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3455784-6586355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3455784-6586356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3455784-6615777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3455784-6627392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3455784-6697388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3455784-6869791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3455784-7000183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3455784-7061443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3455784-7217046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3455784-7250119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3455784-7250120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3455784-7263653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3455784-844098
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
498-502
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3455784-Animals,
pubmed-meshheading:3455784-Antibodies, Monoclonal,
pubmed-meshheading:3455784-Binding, Competitive,
pubmed-meshheading:3455784-Bungarotoxins,
pubmed-meshheading:3455784-Cells, Cultured,
pubmed-meshheading:3455784-DNA,
pubmed-meshheading:3455784-Gene Expression Regulation,
pubmed-meshheading:3455784-Molecular Weight,
pubmed-meshheading:3455784-Protein Precursors,
pubmed-meshheading:3455784-Protein Processing, Post-Translational,
pubmed-meshheading:3455784-Rats,
pubmed-meshheading:3455784-Receptors, Nicotinic,
pubmed-meshheading:3455784-Tubocurarine
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pubmed:year |
1986
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pubmed:articleTitle |
An acetylcholine receptor precursor alpha subunit that binds alpha-bungarotoxin but not d-tubocurare.
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pubmed:publicationType |
Journal Article
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