Linked Life Data

3455593

Source:http://linkedlifedata.com/resource/pubmed/id/3455593

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1988-10-27
pubmed:abstractText
The development and sex differences of the central nervous GABAergic system were examined by measuring GABA (gamma-aminobutyric acid) in discrete brain nuclei of the hypothalamus, as well as the nigrostriatal and the limbic systems of male and female rats on the day of birth and on days 5, 10, and 15. The highest concentrations were found in the hypothalamic and nigrostriatal nuclei; the lowest in the limbic system. Sex differences were observed only on day 10 in the medial preoptic area, with GABA being higher in males than in females; and also in the substantia nigra, where female GABA levels were higher than male. These results suggested an involvement of GABA in the sexual differentiation of the brain. As a control, concentrations of the GABA precursor glutamate were determined. No sex differences in glutamate concentrations were found in any brain region during the first 15 days postnatally. Since a GABA mimetic substance applied during the critical period of brain differentiation could disturb the development of the GABAergic system, the consequences of a perinatal treatment with the GABA agonist muscimol were investigated. Significant reduction of GABA concentrations by muscimol were observed in the hypothalamic and nigrostriatal systems at specific times postnatally. On day 5, GABA concentrations were diminished only in the medial preoptic area, then on day 10, in the anterior hypothalamus and the substantia nigra, and still later, on day 15, in the caudato putamen. In contrast, the effects of muscimol on glutamate concentrations could be observed over a longer postnatal period. Glutamate was already diminished on day 5 in 7 areas of the hypothalamic, nigrostriatal, and limbic systems.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0736-5748
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
319-26
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Postnatal development of transmitter systems: sexual differentiation of the GABAergic system and effects of muscimol.
pubmed:affiliation
Department for Reproductive Biology, Göttingen, F.R.G.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't