Linked Life Data

3455264

Source:http://linkedlifedata.com/resource/pubmed/id/3455264

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1988-10-18
pubmed:abstractText
Kainic acid (KA) is a powerful convulsant and neurotoxic agent. In the present paper the acute and long term effects of intrahippocampal KA administration on estrous cycle and on serum concentrations of progesterone were studied in adult female rats. Following KA injection, 3 distinct periods were observed: 1) acute period (24-48 h), 2) silent period (21-30 days), and 3) chronic period, characterized by the appearance of spontaneous recurrent seizures (30-45 days). KA administration did not affect progesterone levels during the acute period. In contrast, during the silent period, KA-treated animals exhibited irregular estrous cycling and decreased progesterone levels. These results are of interest in view of a possible link between epileptic phenomena and hormone secretion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0100-879X
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
829-32
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Effects of intrahippocampal injection of kainic acid on estrous cycle in rats.
pubmed:affiliation
Departamento de Neurologia e Neurocirurgia, Escola Paulista de Medicina, São Paulo, Brasil.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't