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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1988-9-13
|
| pubmed:abstractText |
Light microscopic morphometric procedures were used in order to examine the effects of propylthiouracil (PTU) on the development of the mesencephalic nucleus of the trigeminal nerve in the duck. A single vascular injection of a 0.2% solution of PTU was administered at a dosage of 2 microliter/gm embryo weight on embryonic day nine (E9). Control embryos received a similar dose of Ringer's solution. The following parameters of cytodifferentiation of cells of the mesencephalic nucleus of V were studied: somal area profiles, nuclear area, and nuclear cytoplasmic ratios. In addition, the frequency of beak clapping was recorded from E16. Significant differences were observed in somal area profiles in the experimental group at E16 and E18 and in nuclear area profiles from E16 through hatching. Beak activity in the experimental embryos was drastically reduced. It is concluded that PTU induces a retardation in the differentiation of cells of the mesencephalic nucleus of V which may lead to behavior deficits as evidenced by reduction of beak activity. These observations provide a basis for the study of interactions between thyroid hormone and specific neuronal systems in the emergence of an adaptive function.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0003-276X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
217
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
79-89
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3454567-Animals,
pubmed-meshheading:3454567-Beak,
pubmed-meshheading:3454567-Ducks,
pubmed-meshheading:3454567-Hypothyroidism,
pubmed-meshheading:3454567-Mesencephalon,
pubmed-meshheading:3454567-Neurons,
pubmed-meshheading:3454567-Propylthiouracil,
pubmed-meshheading:3454567-Thyroid Gland,
pubmed-meshheading:3454567-Trigeminal Nuclei
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Neuronal development in the trigeminal mesencephalic nucleus of the duck under normal and hypothyroid states: I. A light microscopic morphometric analysis.
|
| pubmed:affiliation |
Department of Anatomy, Louisiana State University School of Medicine, New Orleans 70119.
|
| pubmed:publicationType |
Journal Article
|