Linked Life Data

3451675

Source:http://linkedlifedata.com/resource/pubmed/id/3451675

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1988-7-5
pubmed:abstractText
Research in panic disorder (PD) has highlighted a low biological threshold (lactate infusion). Also, several studies have shown neurophysiological changes with PD patients: increased brain perfusion (Stewart), parahypocampal hyper-perfusion (Reiman) and we reported an increased incidence of epileptiform abnormalities. In order to assess neuroanatomical changes we carried out a study with magnetic resonance imaging (MRI) of P.D. as compared to controls. A prospective study with MRI was done with 13 P.D. patients and 10 controls. The inclusion criteria were outpatients with P.D. according to DSM-III criteria. All subjects (patients and controls) were right handed and between 18 and 40 years of age. Usual exclusion criteria were used. A Signa MR machine of 1.5 telsa (General Electric) was used and images in T1, T2 mode were generated. We found a higher percentage of brain atrophy in patients with PD (64%) than with controls (20%) and the differences reached significance (p-.04-Fisher ex. test). Right temporal lobe horn atrophy was the most common finding in P.D. patients. There were no difference between patients and controls for age, sex and weight. We have found anatomical changes in young P.D. patients. Whether this atrophy found with MRI and physiological changes previously reported are related should assessed further. However, our findings support biological factors in the etiology of PD and stimulates the development of better pharmacological treatments.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0300-8967
pubmed:author
pubmed:issnType
Print
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
607-16
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Neurobiology in panic states].
pubmed:affiliation
Centre de recherche, Hôpital Louis H. Lafontaine, Montréal, Québec, Canada.
pubmed:publicationType
Journal Article, English Abstract