Linked Life Data

3446545

Source:http://linkedlifedata.com/resource/pubmed/id/3446545

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1988-5-24
pubmed:abstractText
The effects of dexamethasone, cyclosporin A and prazosin were investigated in an animal model of retinal vasculitis. Both dexamethasone and cyclosporin A reduced the clinical and pathological signs of disease when given from the day of disease onset. Prazosin, an alpha 1 adrenergic antagonist, was given during the period of disease induction and blocked fluorescein leakage from actively inflamed retinal vessels, but had little effect on the clinical and pathological signs of disease. This study demonstrates the feasibility of using this animal model for therapeutic trials of anti-inflammatory agents in retinal vasculitis. The effect of prazosin on reducing vascular leakage from retinal vessels has implications for the treatment of inflammatory macula oedema in human disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0950-222X
pubmed:author
pubmed:issnType
Print
pubmed:volume
1 ( Pt 5)
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
626-31
pubmed:dateRevised
2009-11-3
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Modulation of experimental retinal vasculitis using dexamethasone, cyclosporin A, and prazosin.
pubmed:affiliation
Department of Immunology, Rayne Institute, UMDS, St Thomas' Campus, London.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't