Linked Life Data

3446497

Source:http://linkedlifedata.com/resource/pubmed/id/3446497

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1988-5-13
pubmed:abstractText
In cirrhosis, the phagocytic function of the reticuloendothelial system (RES) is decreased. In order to investigate the mechanisms of the hepatic reduced phagocytic activity present in cirrhosis, the hepatic and splenic uptake of 51Cr sheep red blood cells (SRBC) and of colloidal carbon was measured in three groups of Sprague-Dawley rats. Group 1 consisted of 42 control rats, group 2 of 36 rats with end-to-side portacaval shunt and group 3 of 24 rats with carbon tetrachloride-induced cirrhosis. The hepatic uptake of 51Cr SRBC and of colloidal carbon was significantly (p less than 0.001) reduced in cirrhotic rats (group 3). Conversely, in rats with a portacaval shunt and a noncirrhotic liver (group 2), the hepatic uptake of 51Cr SRBC was moderately reduced, whereas the colloidal carbon hepatic uptake was not found to be decreased. These results suggest that the decreased RES phagocytic activity observed in cirrhotic rats is only partially due to portacaval shunt and that an intrinsic defective activity of hepatic phagocytic cells is probably present.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0014-312X
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
388-94
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Decreased reticuloendothelial phagocytic capacity in cirrhotic and portacaval shunt rats.
pubmed:affiliation
Département de Chirurgie Expérimentale, Hôpital Paul-Brousse, Villejuif, France.
pubmed:publicationType
Journal Article, Comparative Study