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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1988-5-12
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pubmed:abstractText |
1. Standard renal clearance techniques were used to investigate the effects of chronic hyperprolactinaemia on kidney function in male, female and ovariectomized female rats. 2. All hyperprolactinaemic rats showed a significantly increased glomerular filtration rate (G.F.R.) compared to controls. Values were (microliter min-1) 2738 +/- 146 vs. 2299 +/- 99 for males (P less than 0.05), 2236 +/- 79 vs. 1865 +/- 74 for females (P less than 0.01) and 2200 +/- 76 vs. 1941 +/- 62 for ovariectomized females (P less than 0.05). 3. Hyperprolactinaemic rats in all groups also showed a significant increase in absolute tubular reabsorption of water, sodium and chloride compared to their respective controls. Increases here averaged 19%. 4. There was a significantly greater fractional tubular reabsorption of fluid and solutes in hyperprolactinaemic male rats compared to controls. Values were (%) 92.9 +/- 0.6 vs. 90.3 +/- 0.7 for water, 93.0 +/- 0.4 vs. 91.0 +/- 0.6 for sodium and 89.9 +/- 0.7 vs. 86.5 +/- 0.9 for chloride. In each case P less than 0.05. 5. These results imply an osmoregulatory role for prolactin which is not specific to pregnancy or related female reproductive states.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3443963-13161877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3443963-13933866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3443963-3003225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3443963-3017688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3443963-3084766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3443963-4017955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3443963-4045350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3443963-4344064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3443963-4695432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3443963-4815990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3443963-5410439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3443963-6247216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3443963-6248689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3443963-6253591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3443963-6348253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3443963-6890577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3443963-7200137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3443963-7205677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3443963-7297493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3443963-7320910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3443963-7441561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3443963-910825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3443963-944123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3443963-946957
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-3751
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
394
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13-21
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3443963-Absorption,
pubmed-meshheading:3443963-Animals,
pubmed-meshheading:3443963-Female,
pubmed-meshheading:3443963-Glomerular Filtration Rate,
pubmed-meshheading:3443963-Hyperprolactinemia,
pubmed-meshheading:3443963-Kidney,
pubmed-meshheading:3443963-Kidney Tubules,
pubmed-meshheading:3443963-Male,
pubmed-meshheading:3443963-Ovariectomy,
pubmed-meshheading:3443963-Rats,
pubmed-meshheading:3443963-Rats, Inbred Strains
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pubmed:year |
1987
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pubmed:articleTitle |
Altered renal function in chronically hyperprolactinaemic rats.
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pubmed:affiliation |
Department of Physiological Sciences, University of Manchester.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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