Linked Life Data

3443938

Source:http://linkedlifedata.com/resource/pubmed/id/3443938

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1988-5-3
pubmed:abstractText
1. Several studies have hypothesized that alanine decreases plasma ketone body levels by increasing availability of oxaloacetate, thus allowing acetyl groups to enter the tricarboxylic acid cycle and releasing co-enzyme A (CoA). 2. Four, fasted adult males exercised at 50% of their maximal oxygen consumption for 1.5 h, then ingested 100 g of either glucose or alanine 2 h into recovery. 3. Post-exercise ketosis had developed at 2 h into recovery, as shown by a significantly elevated concentration of beta-hydroxybutyrate in the plasma. At this time plasma free fatty acids were elevated above resting levels while plasma free carnitine concentrations had fallen below resting values. 4. After either alanine or glucose ingestion beta-hydroxybutyrate concentrations fell to the same extent. After the alanine load free carnitine increased above that seen in the glucose trial. Following either alanine or glucose ingestion free fatty acid levels fell; they remained at resting levels in the alanine trial but decreased below rest in the glucose trial. 5. We assume that plasma carnitine concentrations largely reflect the hepatic carnitine pools; therefore, elevations in the plasma free carnitine are probably the result of an increased utilization of acetyl CoA. The significant elevation in plasma free carnitine concentration found after alanine ingestion is consistent with the hypothesis that alanine increases the oxidation of acetyl CoA by providing oxaloacetate for the tricarboxylic acid cycle.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3443938-1200987, http://linkedlifedata.com/resource/pubmed/commentcorrection/3443938-16742571, http://linkedlifedata.com/resource/pubmed/commentcorrection/3443938-4436414, http://linkedlifedata.com/resource/pubmed/commentcorrection/3443938-447661, http://linkedlifedata.com/resource/pubmed/commentcorrection/3443938-468816, http://linkedlifedata.com/resource/pubmed/commentcorrection/3443938-4711595, http://linkedlifedata.com/resource/pubmed/commentcorrection/3443938-6112656, http://linkedlifedata.com/resource/pubmed/commentcorrection/3443938-6361812, http://linkedlifedata.com/resource/pubmed/commentcorrection/3443938-6883165, http://linkedlifedata.com/resource/pubmed/commentcorrection/3443938-696819, http://linkedlifedata.com/resource/pubmed/commentcorrection/3443938-7050344, http://linkedlifedata.com/resource/pubmed/commentcorrection/3443938-7181869, http://linkedlifedata.com/resource/pubmed/commentcorrection/3443938-7470064, http://linkedlifedata.com/resource/pubmed/commentcorrection/3443938-761713, http://linkedlifedata.com/resource/pubmed/commentcorrection/3443938-869176, http://linkedlifedata.com/resource/pubmed/commentcorrection/3443938-914970
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-3751
pubmed:author
pubmed:issnType
Print
pubmed:volume
390
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
295-303
pubmed:dateRevised
2010-9-9
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
The effects of post-exercise glucose and alanine ingestion on plasma carnitine and ketosis in humans.
pubmed:affiliation
Department of Preventive Medicine, University of Wisconsin Medical School, Madison 53706.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't