Linked Life Data

3442185

Source:http://linkedlifedata.com/resource/pubmed/id/3442185

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-4-21
pubmed:abstractText
Two thousand six hundred and seventy one liver biopsies were reviewed from 1972 to 1985 at the Hospital A. Posadas. There were 26 patients with drug-induced liver injury; those who fulfilled the following criteria were included: contact with a drug known to produce hepatotoxicity; clinic, biologic and histologic picture corresponding to the drug studied, complete recovery after the drug was stopped and no other hepatic toxics. Fourteen patients showed estrogen-induced intrahepatic cholestasis, 5 had hepatitis-like lesions due to: alphamethyldopa (3), ketoconazole (1) and indomethacin (1). Carbon tetrachloride caused fatty degeneration in two patients and phenylbutazone a granulomatous hepatitis in one patient and cholestatic hepatitis in other. The last three cases were cholestatic lesions after the administration of chlorpromazine allopurinol and penicillin respectively. The evolution in 24 patients was excellent after the drug was withdrawn. Two patients died because of surgical complications since they were operated on with the wrong diagnosis of extrahepatic cholestasis.
pubmed:language
spa
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-9033
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
105-11
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
[Hepatic lesions induced by drugs. Report of 26 cases].
pubmed:affiliation
Hospital Nacional Alejandro Posadas, Haedo, Provincia de Buenos Aires.
pubmed:publicationType
Journal Article, English Abstract