| Subject | Predicate | Object | Context |
|---|---|---|---|
| pubmed-article:3442089 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3442089 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:3442089 | lifeskim:mentions | umls-concept:C0022116 | lld:lifeskim |
| pubmed-article:3442089 | lifeskim:mentions | umls-concept:C0683325 | lld:lifeskim |
| pubmed-article:3442089 | lifeskim:mentions | umls-concept:C2348867 | lld:lifeskim |
| pubmed-article:3442089 | pubmed:dateCreated | 1988-4-8 | lld:pubmed |
| pubmed-article:3442089 | pubmed:abstractText | The vast majority of modern surgical open-heart procedures require a period of global myocardial ischaemia due to the interruption of the coronary circulation, since a bloodless operative field is of great importance for delicate surgical techniques. Several cardiac protective measures have been applied in order to minimize ischaemic damage to the heart muscle: 1. Intermittent myocardial ischaemia, combined with mild to moderate hypothermia: ischaemic periods of 15-30 min at 28-32 degrees C are tolerated. Multiple ischaemic periods are possible after intermittent (3-5 min) reperfusion. 2. Deep hypothermia, combined with ischaemia: myocardial cooling to 18-23 degrees C protects the heart for ischaemic periods of up to 45-60 min. 3. Cardioplegic arrest, combined with hypothermia: a great variety of cardioplegic solutions are still used today in clinical practice. a. Interruption of electrical activity: most cardioplegic solutions use K+ (15-35 mmol/l); complete suppression of electrical processes is not always achieved. b. Interruption of electrical activity and buffering of glycolytic end products. St. Thomas-, Kirklin-Solution, blood cardioplegia and their multiple variations can result in an 3-5 fold tolerance to myocardial ischaemia. c. Interruption and blockade of electro-mechanical activity, combined with an effective buffering. Bretschneider-HTK cardioplegia equilibrates the extracellular space due to a 6-10 min infusion of the cold, crystalloid solution and allows uninterrupted ischaemic periods of more than 2 h under clinical conditions. In order to achieve optimal cardiac tolerance to global ischaemia a careful protocol of perioperative myocardial proection has to be followed. Most heart centers use a combination of hypothermia and effective cardioplegia. | lld:pubmed |
| pubmed-article:3442089 | pubmed:language | ger | lld:pubmed |
| pubmed-article:3442089 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3442089 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3442089 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3442089 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3442089 | pubmed:issn | 0300-5860 | lld:pubmed |
| pubmed-article:3442089 | pubmed:author | pubmed-author:HellbergKK | lld:pubmed |
| pubmed-article:3442089 | pubmed:issnType | lld:pubmed | |
| pubmed-article:3442089 | pubmed:volume | 76 Suppl 4 | lld:pubmed |
| pubmed-article:3442089 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3442089 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3442089 | pubmed:pagination | 25-30 | lld:pubmed |
| pubmed-article:3442089 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3442089 | pubmed:meshHeading | pubmed-meshheading:3442089-... | lld:pubmed |
| pubmed-article:3442089 | pubmed:meshHeading | pubmed-meshheading:3442089-... | lld:pubmed |
| pubmed-article:3442089 | pubmed:meshHeading | pubmed-meshheading:3442089-... | lld:pubmed |
| pubmed-article:3442089 | pubmed:meshHeading | pubmed-meshheading:3442089-... | lld:pubmed |
| pubmed-article:3442089 | pubmed:meshHeading | pubmed-meshheading:3442089-... | lld:pubmed |
| pubmed-article:3442089 | pubmed:meshHeading | pubmed-meshheading:3442089-... | lld:pubmed |
| pubmed-article:3442089 | pubmed:meshHeading | pubmed-meshheading:3442089-... | lld:pubmed |
| pubmed-article:3442089 | pubmed:meshHeading | pubmed-meshheading:3442089-... | lld:pubmed |
| pubmed-article:3442089 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3442089 | pubmed:articleTitle | [Clinical aspects of global ischemia of the heart]. | lld:pubmed |
| pubmed-article:3442089 | pubmed:affiliation | Abteilung für Herz- und Gefässchirurgie, Robert-Bosch-Krankenhaus, Stuttgart. | lld:pubmed |
| pubmed-article:3442089 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3442089 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:3442089 | pubmed:publicationType | English Abstract | lld:pubmed |