Linked Life Data

3442089

Source:http://linkedlifedata.com/resource/pubmed/id/3442089

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1988-4-8
pubmed:abstractText
The vast majority of modern surgical open-heart procedures require a period of global myocardial ischaemia due to the interruption of the coronary circulation, since a bloodless operative field is of great importance for delicate surgical techniques. Several cardiac protective measures have been applied in order to minimize ischaemic damage to the heart muscle: 1. Intermittent myocardial ischaemia, combined with mild to moderate hypothermia: ischaemic periods of 15-30 min at 28-32 degrees C are tolerated. Multiple ischaemic periods are possible after intermittent (3-5 min) reperfusion. 2. Deep hypothermia, combined with ischaemia: myocardial cooling to 18-23 degrees C protects the heart for ischaemic periods of up to 45-60 min. 3. Cardioplegic arrest, combined with hypothermia: a great variety of cardioplegic solutions are still used today in clinical practice. a. Interruption of electrical activity: most cardioplegic solutions use K+ (15-35 mmol/l); complete suppression of electrical processes is not always achieved. b. Interruption of electrical activity and buffering of glycolytic end products. St. Thomas-, Kirklin-Solution, blood cardioplegia and their multiple variations can result in an 3-5 fold tolerance to myocardial ischaemia. c. Interruption and blockade of electro-mechanical activity, combined with an effective buffering. Bretschneider-HTK cardioplegia equilibrates the extracellular space due to a 6-10 min infusion of the cold, crystalloid solution and allows uninterrupted ischaemic periods of more than 2 h under clinical conditions. In order to achieve optimal cardiac tolerance to global ischaemia a careful protocol of perioperative myocardial proection has to be followed. Most heart centers use a combination of hypothermia and effective cardioplegia.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-5860
pubmed:author
pubmed:issnType
Print
pubmed:volume
76 Suppl 4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
25-30
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
[Clinical aspects of global ischemia of the heart].
pubmed:affiliation
Abteilung für Herz- und Gefässchirurgie, Robert-Bosch-Krankenhaus, Stuttgart.
pubmed:publicationType
Journal Article, Comparative Study, English Abstract