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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
1988-4-14
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pubmed:abstractText |
Cisplatin is a recognized neurotoxic agent that commonly causes ototoxicity and peripheral neuropathy. In conjunction with characteristic peripheral neuropathy, two patients treated with high-dose cisplatin developed Lhermitte's sign, a manifestation of posterior column spinal cord pathology. After cisplatin therapy was stopped, this symptom gradually resolved. This suggests that at high doses cisplatin may also cause demyelinating central nervous system lesions involving the spinal cord.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0008-543X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2170-2
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3440227-Adult,
pubmed-meshheading:3440227-Aged,
pubmed-meshheading:3440227-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:3440227-Cisplatin,
pubmed-meshheading:3440227-Demyelinating Diseases,
pubmed-meshheading:3440227-Humans,
pubmed-meshheading:3440227-Male,
pubmed-meshheading:3440227-Paresthesia,
pubmed-meshheading:3440227-Spinal Cord Diseases
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pubmed:year |
1987
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pubmed:articleTitle |
The development of Lhermitte's sign during cisplatin chemotherapy. Possible drug-induced toxicity causing spinal cord demyelination.
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pubmed:affiliation |
Division of Urology, Duke University Medical Center, Durham, North Carolina 27710.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Case Reports
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