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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1978-5-17
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pubmed:abstractText |
Nine patients with chronic lymphocytic leukemia (CLL) who also developed diffuse histiocytic lymphoma (DH) are described. The incidence of patients with CLL developing DH was at least 3.3%. CLL existed for a median of 2 years before the diagnosis of DH. DH presented in 8 patients with abdominal symptoms and/or enlarging lymph nodes, spleen and liver. There were no consistent laboratory abnormalities associated with the onset of DH. In 4 of the patients the DH appeared to be localized. Eight of the 9 patients have died with a median survival of 2 months from the diagnosis of DH. Whether DH occurs as a result of "blastic transformation" of pre-existing CLL or is a second, unrelated malignancy is not certain. It is hypothesized that utilizing current therapies for DH might favorably influence survival.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0008-543X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
422-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:343908-Aged,
pubmed-meshheading:343908-Animals,
pubmed-meshheading:343908-Chick Embryo,
pubmed-meshheading:343908-Female,
pubmed-meshheading:343908-Humans,
pubmed-meshheading:343908-Leukemia, Lymphoid,
pubmed-meshheading:343908-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:343908-Male,
pubmed-meshheading:343908-Middle Aged,
pubmed-meshheading:343908-Neoplasms, Multiple Primary
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pubmed:year |
1978
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pubmed:articleTitle |
Diffuse histiocytic lymphoma complicating chronic lymphocytic leukemia.
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pubmed:publicationType |
Journal Article
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