Linked Life Data

3438046

Source:http://linkedlifedata.com/resource/pubmed/id/3438046

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1988-4-7
pubmed:abstractText
The association with time (0-60 min) of an eye drop preparation containing sodium hyaluronate with the corneal epithelial cell surface was examined using both cryofixation and osmium tetroxide vapor fixation and scanning (SEM) and transmission electron microscopy (TEM). In phosphate-buffered saline (PBS)-treated control eyes of adult mice, 37 postnatal days (PND) old, a variably thick, but well-defined preocular mucus coat was seen, while 5-PND-old animals treated with PBS lacked morphologically detectable mucus at the corneal surface. In mice of both ages, the eye drop preparation was detectable at the corneal surface at time 0 and 5, 15, 30 and 60 min after its application. For these time periods, in both the adult and the pup, the eye drop preparation containing sodium hyaluronate appeared to be composed of electron-dense filamentous material (TEM) which associated with corneal surface cell microvilli. SEM revealed that the eye drop preparation was globular in composition and that its distribution became patchy over the cornea with time for both the adult and the pup.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0030-3747
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
277-84
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Sodium hyaluronate eye drop. A scanning and transmission electron microscopy study of the corneal surface.
pubmed:affiliation
Department of Anatomy/Cell Biology, School of Medicine, Wayne State University, Detroit, Mich.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't