Linked Life Data

3437423

Source:http://linkedlifedata.com/resource/pubmed/id/3437423

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1988-3-25
pubmed:abstractText
Osteoarthritis (OA), characterized by cartilage proteoglycan depletion, synovial inflammation and joint effusion, develops after transection of the anterior cruciate ligament of the canine stifle joint. Synovial villi harvested from the unstable knee of dogs 8 to 14 weeks after cruciate ligament transection and studied in organ culture synthesized more 3H-hyaluronic acid/microgram tissue DNA than villi from the contralateral stifle joints (p less than 0.02). Rates of glycosaminoglycan (GAG) synthesis by synovial cells isolated from the OA joints were comparable to those of synovial cells from contralateral joints, but cells from OA joints tended to proliferate more rapidly (p less than 0.01). Synovial conditioned medium prepared with villi from the OA joints stimulated GAG synthesis and proliferation in synovial cell cultures to a greater extent than either medium prepared with villi from the contralateral knees, or unconditioned medium. Pronase digestion eliminated the stimulatory effect of the conditioned medium. Our results suggest that soluble protein(s) released from the synovium may mediate the synovial proliferation and excessive secretion of hyaluronic acid observed in this arthropathy.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0315-162X
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1150-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Studies of synovial hyaluronic acid synthesis in canine osteoarthritis.
pubmed:affiliation
Rheumatology Service, Veterans Administration Medical Center, Indianapolis, IN 46202.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't