Linked Life Data

3437246

Source:http://linkedlifedata.com/resource/pubmed/id/3437246

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-3-28
pubmed:abstractText
This paper describes the effect of oestradiol-17 beta implants on unbound cytosolic and nuclear oestrogen receptors in the uterus and anterior pituitary gland of ovariectomized adult rats. Rats were ovariectomized and implanted 1 week later with oil or oestradiol-17 beta/oil solution in silicone elastomer capsules. In the latter animals the capsules either remained in situ until decapitation (subgroup 1) or were removed 48 h after implantation (subgroup 2). Implants of oestradiol-17 beta caused a significant depletion in both forms of oestrogen receptor in the uterus and anterior pituitary gland of rats in subgroup 1. In subgroup 2, however, there was an almost complete return to control concentrations of uterine cytosolic receptors and anterior pituitary cytosolic and nuclear receptors. Concentrations of uterine nuclear oestrogen receptors showed only a partial recovery. These data suggest that both forms of oestrogen receptor constitute an integrated population of oestrogen receptors, without dependence on intracellular location, and that in the presence of oestradiol these receptors are bound more quickly than they are synthesized. The results also indicate the existence of a dynamic equilibrium of unbound receptors between the cytosolic and nuclear compartments for both target organs, but show that in the absence of oestradiol this equilibrium is restored in the anterior pituitary sooner than in the uterus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-0795
pubmed:author
pubmed:issnType
Print
pubmed:volume
115
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
205-10
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Relationship between unbound oestrogen receptors in the uterus and anterior pituitary gland after implantation of oestradiol-17 beta into rats.
pubmed:affiliation
Departamento de Farmacología, Colegio Universitario de Las Palmas, Canary Islands, Spain.
pubmed:publicationType
Journal Article