Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-3-15
pubmed:abstractText
Cu2Zn2-superoxide dismutase (CuZn-SOD) was purified from chicken liver. The liver enzyme had a subunit Mr of 16900 and contained equimolar amounts of copper and zinc [0.26% (w/w) for each]. Aortic CuZn-SOD had the same Mr as estimated by gel filtration and cross-reacted with antibodies to the liver enzyme. Both enzymes were inhibited by 1.0 mM-NaCN. Within 24-72 h after hatching, total SOD activity in aorta rose 3-fold over the day-1 level and stayed elevated for 10 days. With low dietary copper, the total SOD activity rose as before, but then decayed progressively to non-detectable levels in 10 days. Both the cyanide-sensitive (CuZn-SOD) and insensitive (mangano-SOD) activities fell, but not at the same rate. When the 10-day-old deficient chicks were injected with 0.5 mumol of CuSO4 intraperitoneally, SOD activity in aorta was restored to control levels in about 8 h. Despite non-measurable SOD activity in aorta, extracts from the 15-day-old-deficient-chick tissue contained as much, or slightly more, immunoreactive CuZn-SOD protein as age-matched control tissue. The data show clearly that dietary copper regulates SOD activity in the aortas of young developing animals. They further suggest that a copper deficiency suppresses CuZn-SOD activity without inhibiting synthesis or accumulation of the CuZn protein in this tissue.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-1055410, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-1153431, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-14240539, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-225457, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-3019662, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-33171, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-3435477, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-3809168, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-3934352, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-41239, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-4215654, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-4279916, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-4346433, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-4346438, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-4371571, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-4373464, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-4697386, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-4702877, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-4984626, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-5389100, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-5432063, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-6111807, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-6312000, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-6700362, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-6724191, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-674233, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-6782377, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-6855576, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-7094535, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-7115349, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-7375720, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-765340, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-851421, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-851422, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-942051, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-947592, http://linkedlifedata.com/resource/pubmed/commentcorrection/3435476-971414
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0264-6021
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
248
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
663-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Regulation of aortic CuZn-superoxide dismutase with copper. Effects in vivo.
pubmed:affiliation
Department of Biochemistry and Biophysics, Texas A & M University, College Station 77843-2128.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't