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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
1988-3-14
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pubmed:abstractText |
Therapeutic efficacy of sulbactam, a beta-lactamase inhibitor, in combination with ampicillin was evaluated in an ampicillin-resistant Pasteurella haemolytica pneumonia model in cattle, using an IV agar emboli method of infection. Groups of cattle given vehicle (group 1, n = 19) or ampicillin (group 2, n = 8) had 74% and 50% mortality, respectively, whereas group 3 (n = 11) given sulbactam-ampicillin had no mortality. Morbidities were 100% in groups 1 and 2 and 27% in group 3. Retrospectively, mortalities and morbidities were significantly (P less than 0.001) lower for group 3 given sulbactam-ampicillin when compared with those in groups 1 and 2 given vehicle or ampicillin, respectively. Evidence of embolic pneumonic pasteurellosis was observed histologically.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0002-9645
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1684-8
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:3434913-Ampicillin,
pubmed-meshheading:3434913-Ampicillin Resistance,
pubmed-meshheading:3434913-Animals,
pubmed-meshheading:3434913-Cattle,
pubmed-meshheading:3434913-Cattle Diseases,
pubmed-meshheading:3434913-Drug Combinations,
pubmed-meshheading:3434913-Drug Resistance, Microbial,
pubmed-meshheading:3434913-Drug Synergism,
pubmed-meshheading:3434913-Injections, Intramuscular,
pubmed-meshheading:3434913-Pasteurella Infections,
pubmed-meshheading:3434913-Pneumonia,
pubmed-meshheading:3434913-Sulbactam
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pubmed:year |
1987
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pubmed:articleTitle |
Efficacy of sulbactam-ampicillin in an induced Pasteurella haemolytica pneumonia model in calves.
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pubmed:affiliation |
Animal Health Research Department, Pfizer Central Research, Terre Haute, IN 47808.
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pubmed:publicationType |
Journal Article
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