Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1988-3-7
pubmed:abstractText
Using fluorescent calcium indicator quin2, we studied intracellular free calcium concentration in platelets that have a number of features similar to vascular smooth muscle cells. Intracellular free calcium concentration in platelets of male SHR was significantly higher at 4, 11 and 28 weeks old compared with age-matched male WKY. However, no significant difference was observed in platelets cytosolic free calcium level of DOCA-salt hypertensive and two-kidney, one clip hypertensive rats in the chronic stage. Cardiac Ca++ channels were estimated by means of radioligand binding method with [3H]-nimodipine. No significant changes were observed in the concentration and affinity of cardiac Ca++ channel in SHR, DOCA-salt hypertensive and two-kidney, one clip hypertensive rats. Calmodulin levels in mesenteric arteries of SHR were significantly decreased in comparison with those of WKY. However no significant differences were observed in DOCA-salt hypertensive rats in the chronic stage. These results indicate that the increase in intracellular free calcium concentration of SHR is not the secondary change caused by high blood pressure. It is impossible to detect the ratio of the three states (open, resting and inactivated) of Ca++ channel. Therefore, there remains a possibility of the changes in the ratio of the states of Ca++ channel. The observed abnormalities of Ca++ regulation may contribute to the pathogenesis of hypertension.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0047-1828
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1216-22
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:3430691-Animals, pubmed-meshheading:3430691-Blood Platelets, pubmed-meshheading:3430691-Blood Pressure, pubmed-meshheading:3430691-Body Fluids, pubmed-meshheading:3430691-Calcium, pubmed-meshheading:3430691-Calmodulin, pubmed-meshheading:3430691-Desoxycorticosterone, pubmed-meshheading:3430691-Fluorescence, pubmed-meshheading:3430691-Hypertension, pubmed-meshheading:3430691-Intracellular Fluid, pubmed-meshheading:3430691-Male, pubmed-meshheading:3430691-Mesenteric Arteries, pubmed-meshheading:3430691-Muscle, Smooth, Vascular, pubmed-meshheading:3430691-Myocardium, pubmed-meshheading:3430691-Radioimmunoassay, pubmed-meshheading:3430691-Radioligand Assay, pubmed-meshheading:3430691-Rats, pubmed-meshheading:3430691-Rats, Inbred SHR, pubmed-meshheading:3430691-Rats, Inbred WKY
pubmed:year
1987
pubmed:articleTitle
Intracellular free calcium concentration, Ca++ channel and calmodulin level in experimental hypertension in rats.
pubmed:affiliation
Department of Medicine, Wakayama Medical College, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't