Linked Life Data

3430487

Source:http://linkedlifedata.com/resource/pubmed/id/3430487

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-3-15
pubmed:abstractText
The effect of aging on the immune response to autoantigen of rat male accessory glands (RAG) was studied in Wistar rats. Male and female rats, 3 and 12 months old, were immunized with chemically modified RAG and heterologous antigen (human serum albumin, HSA). The study of delayed type hypersensitivity (DTH) and antibodies against RAG revealed a higher response in 12-month-old animals than in 3-month-old animals (P less than 0.005), regardless of their sexes. No differences in DTH and humoral responses to HSA were observed. Experiments on the transfer of spleen cells showed an increase in response elicited by RAG immunization in young recipients of cells from normal or immunized old syngeneic donors. On the contrary, old recipients of spleen cells from normal or immunized young donors maintained their high response the same as non-transferred old rats. Therefore, both the lymphoid cells and the environment in which the response was elicited seem to be involved in the increase of the autoimmune response.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0165-0378
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
215-23
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Effect of aging on the autoimmune response to sex accessory glands in male rats.
pubmed:affiliation
Cátedra de Immunología y Serología Facultad de Ciencias Químicas, Universidad Nacional Cordoba, Argentina.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't