Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1988-3-14
pubmed:abstractText
It is well accepted that breast-feeding enhances the ability of newborns and infants to be protected against infection. Maternal nutritional status may affect this passive immunological defense mechanism because of either the change in the volume of milk or the alteration of the immunological components secreted in the milk. Diet restriction in lactating dams has been shown to influence the secretion of immunoglobulin in their milk. We investigated the specific role of caloric or protein restriction on immunoglobulin A (IgA) and IgG2a secretion in the milk of lactating rats. Both calorie- and protein-restricted dams had lower protein levels (milligrams per milliliter) than did the controls during the initial days of lactation (P less than 0.05). The levels (milligrams per milligram of protein) of IgA and IgG were higher in the milk obtained from calorie-restricted dams during the whole lactation period. The amount of IgA in the milk of protein-restricted rats was higher during 21 days of lactation, while the amount of IgG2a was higher only during the first 2 weeks of the lactation period compared with the respective values for the milk from control dams (P less than 0.05). Rats on a protein-restricted diet had lower IgA and IgG2a levels in their milk than those on a calorie-restricted diet at the second half of the lactation period (P less than 0.05). Our data suggest that the diet-restricted dams had a compensatory mechanism to ensure passive immunological protection for their pups during lactation. The compensation was diminished with a protein-restricted diet compared with a calorie-restricted diet.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-1129326, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-13212472, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-305474, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-343567, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-3484436, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-3965593, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-416193, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-4168855, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-4174285, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-4208452, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-4293824, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-4455904, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-4996061, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-568655, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-592316, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-6107547, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-6449145, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-6541120, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-6690613, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-6741532, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-6837495, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-7021421, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-7043383, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-7196944, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-7251055, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-7405883, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-769625, http://linkedlifedata.com/resource/pubmed/commentcorrection/3429624-803998
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0095-1137
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2322-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Immunoglobulins A and G2a in milks of protein- and calorie-restricted dams.
pubmed:affiliation
International Institute for Infant Nutrition and Gastrointestinal Disease, Children's Hospital of Buffalo, New York 14222.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't