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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
|
pubmed:dateCreated |
1988-3-23
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pubmed:abstractText |
A pharmacokinetic study was carried out in two infants and two (older) children with high-dose cisplatin (CP) (40 mg/m2/day) by 5-day continuous infusion. Following interruption of the infusion, the decrease in total plasma platinum was biphasic, with a terminal half-life of 155.5-418 h. During administration the urinary concentrations were between 7.66 and 15.2 mg/l. Thirty to thirty five per cent of the administered dose was eliminated within 48 h of discontinuing infusion. Free platinum (FP) levels declined in a biphasic manner, with a mean (+/- S.E.) elimination half-life of 81.25 (+/- 34.9) h. FP was still detectable in the plasma 10 days after the end of infusion with levels above 0.010 micrograms/ml. FP availability, measured as the area under the curves (AUC) of the FP concentration--up to 2 h after ending the infusion--were 768 (+/- 326) micrograms.min/ml. Inter- or intra-individual differences in AUC values were not observed.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0277-5379
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1649-52
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3428333-Child,
pubmed-meshheading:3428333-Cisplatin,
pubmed-meshheading:3428333-Humans,
pubmed-meshheading:3428333-Infant,
pubmed-meshheading:3428333-Infusions, Parenteral,
pubmed-meshheading:3428333-Neuroblastoma,
pubmed-meshheading:3428333-Platinum,
pubmed-meshheading:3428333-Rhabdomyosarcoma
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pubmed:year |
1987
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pubmed:articleTitle |
Continuous infusion of high-dose cisplatin in children: pharmacokinetics of free and total platinum.
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pubmed:affiliation |
Laboratoire Hospitalo-Universitaire de Pharmacocinétique, U278, Faculté de Pharmacie, Marseille, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|