Linked Life Data

3428311

Source:http://linkedlifedata.com/resource/pubmed/id/3428311

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1988-3-3
pubmed:abstractText
The study included 19 parkinsonian patients presenting with fluctuations in motor performance after L-dopa therapy (9.9 years on average, range 6 months to 17 years) and 2 other patients not pretreated with L-dopa. In all patients of the first group, after 3 months on stable 'optimal' dosage schedule, the previous L-dopa treatment was abruptly replaced, dose for dose, from one day to another by Madopar HBS, a new controlled-release form of Madopar. The first clinical assessment was performed just before the beginning of the HBS treatment. Then, 4-6 weeks were allowed to optimize the dosage schedule of Madopar HBS before performing a second assessment. Long-term therapeutic effects were systematically evaluated after 6 and 12 months. Catamnestic evaluation took place at the last check-up for patients treated for more than 1 year. Of the 19 patients with fluctuations 1 dropped out after 7 days due to lack of cooperation. Thus, 18 of these patients were evaluable. At the end of the dose adaptation phase 12 patients (2/3) were better controlled by the new dosage form and were eligible for a long-term follow-up aiming to evaluate the maintenance of the benefit. It was concluded that in most of the patients the initial benefit was maintained during 1 year and even up to 2 years and 7 months for some of them. The best results were obtained in patients with mild to moderate forms of fluctuations (early stage). Positive results in de novo cases need confirmation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0014-3022
pubmed:author
pubmed:issnType
Print
pubmed:volume
27 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
98-104
pubmed:dateRevised
2009-12-23
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Therapeutic value of Madopar HBS: judgment after 2 years experience.
pubmed:affiliation
Neurochirurgische Klinik, Universitätsspital, Zürich, Switzerland.
pubmed:publicationType
Journal Article