Linked Life Data

3427423

Source:http://linkedlifedata.com/resource/pubmed/id/3427423

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-2-26
pubmed:abstractText
Retinas from two rabbits, one normally pigmented and one albino, were labeled with monoclonal antibody AB5, which has been shown to be a specific marker for ganglion cells. This method obviates criteria for distinguishing among ganglion cells, displaced amacrine cells, and glia. Labeled cells were counted within small fields at some 2000 regularly spaced points on each retina. These counts were transformed to maps of ganglion cell density. In general, the density map for the pigmented retina was similar to those obtained by earlier studies with non-specific stains, thereby confirming the basic validity of most previous studies and demonstrating the applicability of AB5 labeling to work of this type. The ganglion cell density map of the albino retina was abnormal, showing a clear deficit of ganglion cells in the nasal portion of the visual streak. This result not only indicates that the albino anomaly has retinal effects, but also suggests a major impact on ganglion cells whose projections (in normal animals) are contralateral.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
425
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
25-33
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Ganglion cell density in albino and pigmented rabbit retinas labeled with a ganglion cell-specific monoclonal antibody.
pubmed:affiliation
School of Optometry, University of Alabama at Birmingham 35294.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't