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rdf:type |
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lifeskim:mentions |
umls-concept:C0000966,
umls-concept:C0001962,
umls-concept:C0011744,
umls-concept:C0036751,
umls-concept:C0233656,
umls-concept:C0332120,
umls-concept:C0598405,
umls-concept:C0728899,
umls-concept:C1514468,
umls-concept:C1515655,
umls-concept:C1522492
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pubmed:dateCreated |
1988-3-23
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pubmed:abstractText |
Trideuterated 5-hydroxymethtryptoline was found in the urine of rats treated with trideuterated ethanol. The combined treatment with disulfiram lead to a more than 10-fold increase in the excretion rate. The chiral analysis revealed unequal abundance of enantiomers suggesting the involvement of a stereoselective (enzymatic) mechanism in the formation 5-hydroxymethtryptoline during ethanol intoxication.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:issn |
1358-6173
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
743-7
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pubmed:dateRevised |
2008-2-26
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pubmed:meshHeading |
pubmed-meshheading:3426756-Acetaldehyde,
pubmed-meshheading:3426756-Alcoholic Intoxication,
pubmed-meshheading:3426756-Animals,
pubmed-meshheading:3426756-Carbolines,
pubmed-meshheading:3426756-Ethanol,
pubmed-meshheading:3426756-Gas Chromatography-Mass Spectrometry,
pubmed-meshheading:3426756-Male,
pubmed-meshheading:3426756-Rats,
pubmed-meshheading:3426756-Rats, Inbred Strains,
pubmed-meshheading:3426756-Serotonin
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pubmed:year |
1987
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pubmed:articleTitle |
Serotonin condensation product 5-hydroxymethtryptoline: evidence for in vivo formation from acetaldehyde during intoxication using deuterium labelled ethanol.
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|
pubmed:affiliation |
Pasarow Analytical Neurochemical Facility, Nancy Pritzker Laboratory of Behavioral Neurochemistry, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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