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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1988-1-28
|
| pubmed:abstractText |
In a survey of institutions for crippled persons in Zimbabwe, 58 patients with osteogenesis imperfecta (OI) were identified; 42 had the rare OI Type III. The Shona and Ndebele people, who comprise the major tribal groups in Zimbabwe, both had a similar and relatively high gene frequency for this disorder. Both tribes were derived from common progenitors, but until 150 years ago had been geographically separated for 2 millenia. Subsequently, they have remained culturally and socially distinct. The implications are that the mutation for OI III in Africa occurred at least 2,000 years ago.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0148-7299
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
27
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
907-12
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3425600-Female,
pubmed-meshheading:3425600-Gene Frequency,
pubmed-meshheading:3425600-Humans,
pubmed-meshheading:3425600-Male,
pubmed-meshheading:3425600-Mutation,
pubmed-meshheading:3425600-Osteogenesis Imperfecta,
pubmed-meshheading:3425600-Pregnancy,
pubmed-meshheading:3425600-Zimbabwe
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Osteogenesis imperfecta type III: an ancient mutation in Africa?
|
| pubmed:affiliation |
Department of Human Genetics, Medical School, University of Cape Town, South Africa.
|
| pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|