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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1988-4-21
|
| pubmed:abstractText |
A group of nine well-nourished patients, with normal serum vitamin K1 levels (mean 546, range 310-1350 pg/ml), maintained normal prothrombin times (PTs) and factor VII clotting activities throughout a 7 d course of i.v. cefotetan disodium, an N-methyl-thiotetrazole (NMTT) containing cephalosporin antibiotic. However, 11 of 20 patients, with acute intra-abdominal sepsis and initially normal PTs who underwent emergency surgery, developed prolonged PTs (INR 1.4-3.1) associated with reduction in factor VII activities (0.74-0.38 u/ml) after 3-7 d of antibiotic therapy. Nine of these 11 patients had clinical evidence of malnutrition and nine had subnormal serum vitamin K1 levels (mean 119, range 43-354 pg/ml) on admission. Seven received cefotetan but four were treated with a non-NMTT-containing cephalosporin or antibiotics belonging to other groups. The nine patients who maintained normal PTs all had normal nutritional status and normal serum vitamin K1 levels (mean 279, range 103-915 pg/ml) at presentation. The PT is a relatively insensitive indicator of vitamin K stores, and malnourished patients with low serum vitamin K1 levels are at risk of developing hypoprothrombinaemia following intravenous antibiotic therapy.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0007-1048
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
68
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
63-6
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:3422816-Adult,
pubmed-meshheading:3422816-Aged,
pubmed-meshheading:3422816-Aged, 80 and over,
pubmed-meshheading:3422816-Blood Coagulation Tests,
pubmed-meshheading:3422816-Cefotetan,
pubmed-meshheading:3422816-Cephamycins,
pubmed-meshheading:3422816-Humans,
pubmed-meshheading:3422816-Hypoprothrombinemias,
pubmed-meshheading:3422816-Middle Aged,
pubmed-meshheading:3422816-Nutrition Disorders,
pubmed-meshheading:3422816-Vitamin K 1,
pubmed-meshheading:3422816-Vitamin K Deficiency
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
The development of hypoprothrombinaemia following antibiotic therapy in malnourished patients with low serum vitamin K1 levels.
|
| pubmed:affiliation |
Department of Haematology, Middlesex Hospital, London.
|
| pubmed:publicationType |
Journal Article
|