3422743

Source:http://linkedlifedata.com/resource/pubmed/id/3422743

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0015980, umls-concept:C0017337, umls-concept:C0086418, umls-concept:C0185027, umls-concept:C0205160, umls-concept:C0220905, umls-concept:C1446409, umls-concept:C1514562, umls-concept:C1880389, umls-concept:C1883204, umls-concept:C1883221
pubmed:issue	5
pubmed:dateCreated	1988-4-1
pubmed:abstractText	Virus or poly(I).poly(C) induction of human beta-interferon gene expression requires a 40-base-pair DNA sequence designated the interferon gene regulatory element (IRE). Previous studies have shown that the IRE contains both positive and negative regulatory DNA sequences. To localize these sequences and study their interactions, we have examined the effects of a large number of single-base mutations within the IRE on beta-interferon gene regulation. We find that the IRE consists of two genetically separable positive regulatory domains and an overlapping negative control sequence. We propose that the beta-interferon gene is switched off in uninduced cells by a repressor that blocks the interaction between one of the two positive regulatory sequences and a specific transcription factor. Induction would then lead to inactivation or displacement of the repressor and binding of transcription factors to both positive regulatory domains.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/3422743-2985279, http://linkedlifedata.com/resource/pubmed/commentcorrection/3422743-2990046, http://linkedlifedata.com/resource/pubmed/commentcorrection/3422743-3032451, http://linkedlifedata.com/resource/pubmed/commentcorrection/3422743-3296191, http://linkedlifedata.com/resource/pubmed/commentcorrection/3422743-3708688, http://linkedlifedata.com/resource/pubmed/commentcorrection/3422743-3708689, http://linkedlifedata.com/resource/pubmed/commentcorrection/3422743-3773893, http://linkedlifedata.com/resource/pubmed/commentcorrection/3422743-3986910, http://linkedlifedata.com/resource/pubmed/commentcorrection/3422743-6091048, http://linkedlifedata.com/resource/pubmed/commentcorrection/3422743-6313211, http://linkedlifedata.com/resource/pubmed/commentcorrection/3422743-6575385
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7505876
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Interferon Type I, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	0027-8424
pubmed:author	pubmed-author:GoodbournSS, pubmed-author:ManiatisTT
pubmed:issnType	Print
pubmed:volume	85
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1447-51
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:3422743-DNA Mutational Analysis, pubmed-meshheading:3422743-Humans, pubmed-meshheading:3422743-Interferon Type I, pubmed-meshheading:3422743-Promoter Regions, Genetic, pubmed-meshheading:3422743-Regulatory Sequences, Nucleic Acid, pubmed-meshheading:3422743-Transcription Factors
pubmed:year	1988
pubmed:articleTitle	Overlapping positive and negative regulatory domains of the human beta-interferon gene.
pubmed:affiliation	Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't