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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1978-4-26
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pubmed:abstractText |
Using several immunological techniques, it was possible to demonstrate that toxicity of human serum in the foetal mouse liver cell bioassay for erythropoietin was due to complement-dependent IgM hetero antibodies to mouse foetal liver cells. The titre of the antibodies in 50 normal human sera ranged between 2 and 64 as measured in an agglutination test with mouse erythrocytes. Specificity of the antibodies for the ABO-or Ii-blood group system could not be established. Inactivation of complement by heating a serum for 30 minutes at 56 degrees C abolished toxicity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0301-472X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
193-200
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:342266-Agglutination Tests,
pubmed-meshheading:342266-Animals,
pubmed-meshheading:342266-Antibodies,
pubmed-meshheading:342266-Biological Assay,
pubmed-meshheading:342266-Blood,
pubmed-meshheading:342266-Complement System Proteins,
pubmed-meshheading:342266-Erythropoietin,
pubmed-meshheading:342266-Fluorescent Antibody Technique,
pubmed-meshheading:342266-Heme,
pubmed-meshheading:342266-Hemolysis,
pubmed-meshheading:342266-Hot Temperature,
pubmed-meshheading:342266-Humans,
pubmed-meshheading:342266-Immunoglobulin Fragments,
pubmed-meshheading:342266-Immunoglobulin G,
pubmed-meshheading:342266-Immunoglobulin M,
pubmed-meshheading:342266-Liver,
pubmed-meshheading:342266-Mice
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pubmed:year |
1978
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pubmed:articleTitle |
The nature of toxicity of human serum in the bioassay for erythropoietin using mouse foetal liver cells.
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pubmed:publicationType |
Journal Article
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