|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0020517,
umls-concept:C0021853,
umls-concept:C0026724,
umls-concept:C0031164,
umls-concept:C0033684,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0205266,
umls-concept:C0242209,
umls-concept:C0243144,
umls-concept:C1707520,
umls-concept:C1879547
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1988-3-3
|
|
pubmed:abstractText |
We have confirmed previous observations that intestinal anaphylaxis induced in rats previously sensitized to ovalbumin (OVA) is associated with an increased uptake of an unrelated 'bystander' protein, bovine serum albumin (BSA) fed 1 hr previously. In this study, this enhanced protein uptake was associated with an increased lactulose/rhamnose excretion ratio after administration of these sugars, although there was no correlation between the two measurements. One hour after antigen challenge the serum levels of rat mast-cell protease II (RMCPII), a specific marker for mucosal mast-cell secretion, were significantly higher than both the pre-challenge levels and those of sham-challenged controls (P less than 0.002). There was a significant positive correlation between the serum levels of RMCPII and the lactulose/rhamnose excretion ratios (P less than 0.05), but no such correlation existed between RMCPII and BSA levels in the challenged rats. In other studies the urinary lactulose/rhamnose ratios of rats with cetrimide-induced gut damage were found to be significantly increased, although BSA uptake into the serum remained unaltered. We conclude that there is no simple correlation between gut permeation of low-molecular weight sugars and and the uptake of macromolecular proteins.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422220-111875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422220-2579878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422220-3745938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422220-4023632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422220-5851951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422220-6112605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422220-6345346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422220-637512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422220-6437913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422220-6601473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422220-6786813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422220-6896019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422220-7192196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422220-7204787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422220-819192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3422220-87729
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0019-2805
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
63
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
119-24
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:3422220-Animals,
pubmed-meshheading:3422220-Chymases,
pubmed-meshheading:3422220-Disaccharides,
pubmed-meshheading:3422220-Female,
pubmed-meshheading:3422220-Food Hypersensitivity,
pubmed-meshheading:3422220-Intestinal Absorption,
pubmed-meshheading:3422220-Intestinal Mucosa,
pubmed-meshheading:3422220-Lactulose,
pubmed-meshheading:3422220-Male,
pubmed-meshheading:3422220-Mast Cells,
pubmed-meshheading:3422220-Ovalbumin,
pubmed-meshheading:3422220-Permeability,
pubmed-meshheading:3422220-Rats,
pubmed-meshheading:3422220-Rats, Inbred Strains,
pubmed-meshheading:3422220-Rhamnose,
pubmed-meshheading:3422220-Serine Endopeptidases,
pubmed-meshheading:3422220-Serum Albumin, Bovine
|
|
pubmed:year |
1988
|
|
pubmed:articleTitle |
Intestinal hypersensitivity reactions in the rat. I. Uptake of intact protein, permeability to sugars and their correlation with mucosal mast-cell activation.
|
|
pubmed:affiliation |
Department of Immunology, Institute of Child Health, London, U.K.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
