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pubmed:abstractText |
The effects of subanaesthetic doses of etomidate on corticosteroid synthesis have been studied in vivo. In the group of patients who received etomidate (n = 10), cortisol and aldosterone responses to adrenocorticotrophic hormone were blunted, while 11-de-oxycortisol response was increased, as compared to a control group (n = 10). These results suggest that a single bolus of 0.04 mg/kg etomidate, which produces sedation, without loss of consciousness, is able to block adrenal 11 hydroxylase.
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pubmed:affiliation |
Department of Nuclear Medicine, Valdecilla Hospital, School of Medicine, University of Cantabria, Santander, Spain.
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