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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1978-4-17
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pubmed:abstractText |
1 Extraneuronal uptake of noradrenaline and alpha-methylnoradrenaline into single cells of guinea-pig tracheal smooth muscle have been studied by means of quantitative fluorescence microphotometry. 2 Fluorescence brightness due to accumulation of alpha-methylnoradrenaline was dose-dependent and was increased by the catechol-O-methyltransferase inhibitor drugs, tropolone or beta-thujaplicin (200 micrometer) but not by 3,4-dimethoxy-5-hydroxybenzoic acid (200 microgram). 3 Fluorescence brightness due to accumulation of noradrenaline was increased if animals were pretreated with the monoamine oxidase inhibitor drug, nialamide. 4 The study suggests that metabolism of amines by catechol-O-methyltransferase and monoamine oxidase can occur subsequent to extraneuronal uptake is guinea-pig tracheal smooth muscle. 5 The uptake of noradrenaline into tracheal smooth muscle was concentration-dependent, saturable, and had a Km of 156 micrometer.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
235-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:342032-Animals,
pubmed-meshheading:342032-Catechol O-Methyltransferase,
pubmed-meshheading:342032-Guinea Pigs,
pubmed-meshheading:342032-Kinetics,
pubmed-meshheading:342032-Microscopy, Fluorescence,
pubmed-meshheading:342032-Muscle, Smooth,
pubmed-meshheading:342032-Nialamide,
pubmed-meshheading:342032-Nordefrin,
pubmed-meshheading:342032-Norepinephrine,
pubmed-meshheading:342032-Photometry,
pubmed-meshheading:342032-Trachea
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pubmed:year |
1978
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pubmed:articleTitle |
The uptake kinetics and metabolism of extraneuronal noradrenaline in guinea-pig trachea as studied with quantitative fluorescence microphotometry.
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pubmed:publicationType |
Journal Article,
In Vitro
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