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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1988-10-20
|
| pubmed:abstractText |
The biologic actions of vasoactive intestinal polypeptide (VIP) on insulin binding, glucose uptake and utilization, and on lipolysis were studied. At concentrations between 10(-10) and 10(-7) mol/l VIP influenced neither glucose uptake nor glucose incorporation into lipids under basal and insulin-stimulated conditions. This effect was independent of the presence of adenosine deaminase in the incubation medium. At 10(-8) mol/l VIP increased insulin binding affinity slightly but not significantly, shifting the ID-50 from 12.4 ng/ml to 10.3 ng/ml, without any change in receptor number. However, VIP showed a marked dose-dependent lipolytic activity with the lowest effective concentration at 10(-9) mol/l. At 10(-6) mol/l glycerol release increased 7.3-fold as compared to basal lipolysis. In conclusion, VIP did not affect adipose tissue metabolism at physiologic concentrations. In the rare Verner-Morrison syndrome, however, the potent lipolytic activity of VIP may contribute to the metabolic disturbances observed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0300-9130
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
188
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
189-95
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading | |
| pubmed:year |
1988
|
| pubmed:articleTitle |
Effect of vasoactive intestinal polypeptide (VIP) on glucose and lipid metabolism of isolated rat adipocytes.
|
| pubmed:affiliation |
Abteilung Innere Medizin I, Universitätsklinik Ulm, Federal Republic of Germany.
|
| pubmed:publicationType |
Journal Article
|